Jennifer Koehler

1 month ago | science.org | John K. Mich |Jennifer Koehler |Itay Raphael |Raphaël Porret |Olivia Hoffman |Anna Patterson | +8 more

Editor’s summaryMost patients with epilepsy require lifelong medication for seizure management. Hoffman et al. identified Stat3 as a hub gene that regulates transcriptomic changes in the brains of mice after status epilepticus (SE) and in patients with temporal lobe epilepsy. In mice, JAK/STAT signaling was transiently induced during SE and reactivated in the chronic phase weeks after the induction of SE.