Jennifer Lees

Sep 11, 2024 | digitalcommons.library.tmc.edu | Dominic McGovern |Jennifer Lees |Jamie P. Traynor |Bruce MacKinnon

INTRODUCTION: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) causes autoimmune-mediated inflammation of small blood vessels in multiple organs, including the kidneys. The ability to accurately predict kidney outcomes would enable a more personalized therapeutic approach. METHODS: We used our national renal biopsy registry to validate the ability of ANCA Renal Risk Score (ARRS) to predict end-stage kidney disease (ESKD) for individual patients.

Jul 3, 2024 | nordiclifescience.org | Jennifer Lees

Challenges and Funding Dilemmas from an International and Nordic Perspective. It is no secret that obesity is one of the biggest public health challenges of the 21st century and is one of the leading causes of preventable death globally. It’s estimated that 18% of the global population is obese, with the prevalence of obesity in the Nordics at somewhere between 15% to 21%, with these numbers only expected to rise.

Jul 26, 2023 | nature.com | Jennifer Lees |Patrick B. Mark

Kidney failure is a serious but rare consequence of progressive chronic kidney disease. A meta-analysis of individual participant-level trial data, across heterogeneous treatments and disease groups, has shown glomerular filtration rate (GFR) slope to be a valid, fit-for-purpose and robust surrogate marker of kidney failure. Refers to Inker, L. A. et al. A meta-analysis of GFR slope as a surrogate endpoint for kidney failure. Nat. Med. https://doi.org/10.1038/s41591-023-02418-0 (2023).

Jun 27, 2023 | nature.com | Kaitlin J. Mayne |Jennifer Lees

IntroductionHypertension is both a precursor to and a sequela of chronic kidney disease (CKD). Hypertension is increasingly prevalent as kidney function declines and occurs in between 60 and 90% of individuals with CKD [1]. Optimisation of blood pressure control reduces cardiovascular risk in CKD and may slow kidney disease progression [1] thus blood pressure control is a critical component of CKD management.