Jennifer Schaub

Apr 3, 2024 | nature.com | Paola Fioretto |Frederik Persson |Sylvia E. Rosas |Peter Rossing |Jennifer Schaub |Katherine R. Tuttle | +1 more

AbstractDiabetic kidney disease (DKD), defined as co-existing diabetes and chronic kidney disease in the absence of other clear causes of kidney injury, occurs in approximately 20–40% of patients with diabetes mellitus. As the global prevalence of diabetes has increased, DKD has become highly prevalent and a leading cause of kidney failure, accelerated cardiovascular disease, premature mortality and global health care expenditure.

Mar 1, 2023 | jci.org | Katherine R. Tuttle |Jennifer Schaub |Matthias Kretzler |Petter Bjornstad

AbstractThe sodium-glucose cotransporter-2 (SGLT2) is expressed on the luminal side of proximal tubule epithelial cells in the kidney. While pharmacological inhibition of SGLT2 provides kidney protection in diabetic kidney disease (DKD), the molecular mechanisms remain unclear. In this issue of the JCI, Schaub et al. report on the changes in single-cell transcriptional profiles of young participants with type 2 diabetes who received SGLT2 inhibitors.