Jennifer Tsang

Boston

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Articles

Developing drugs faster with flycode antibody tags

2 weeks ago | drugdiscoverynews.com | Jennifer Tsang

In the search for promising drug candidates that will make their way to approval, drug developers sift through thousands of molecules to find the best one for clinical trials. To narrow it down, part of the process involves tracking where the drugs go in the body and how long they stay there. For small molecule drugs, there are ways to test multiple drug candidates within the same mouse. But scientists must test therapeutic antibody drugs exhaustively one at a time in mice.
Engineering bacteriophages to produce proteins in the gut

1 month ago | drugdiscoverynews.com | Jennifer Tsang

By using phages to deliver genes for therapeutic proteins, biologic drug delivery could become much easier. Credit: iStock.com/Marharyta MarkoBy using phages to deliver genes for therapeutic proteins, biologic drug delivery could become much easier. | 4 min readJennifer Tsang, PhDRegister for free to listen to this articleBiologic drugs have opened the door to treating diseases that were once considered difficult or impossible to treat.
Predicting postpartum depression during pregnancy

Feb 26, 2025 | drugdiscoverynews.com | Jennifer Tsang

Postpartum depression (PPD) affects nearly 20 percent of childbearing people, but just three percent receive treatment until their symptoms resolve (1,2). Lauren Osborne, a reproductive psychiatrist at Weill Cornell Medicine/New York-Presbyterian Hospital said that this is partly because “we aren't good at figuring out who's going to be at risk and getting them into care early.” What if there was a way to better predict and treat people before PPD develops?
Diagnostics for faster antimicrobial susceptibility testing

Feb 18, 2025 | drugdiscoverynews.com | Jennifer Tsang

New phenotypic methods can help identify the best antibiotic to treat sepsis, UTIs, and other bacterial infections. Credit: Martin Oeggerli (Micronaut) and Resistell 2021New phenotypic methods can help identify the best antibiotic to treat sepsis, UTIs, and other bacterial infections.
Optimizing antibiotics out of worm guts

Feb 13, 2025 | drugdiscoverynews.com | Jennifer Tsang

In vivo studies of the antibiotic darobactin D22 against high-priority gram-negative bacteria show promise for further drug development. In vivo studies of the antibiotic darobactin D22 against high-priority gram-negative bacteria show promise for further drug development. | 3 min readJennifer Tsang, PhDRegister for free to listen to this articleIn the innermost layer of a parasitic worm sits the starting material for what may become a powerful new antibiotic.
Towards an AI-Driven CRISPR Future

Feb 11, 2025 | synbiobeta.com | Jennifer Tsang

Since the discovery of Cas9, scientists have been identifying other CRISPR enzymes in attempts to find enzymes that are better fit for purpose - those that cut more efficiently, those that are smaller and thus easier to package in gene therapy vectors, or those that have minimal off-target editing. Scientists have been optimizing CRISPR systems for years, and now, with the rise of AI in biotech, many in the field have been using AI to design the best CRISPR system.
Toward an AAV gene therapy to treat muscular dystrophies

Feb 6, 2025 | drugdiscoverynews.com | Jennifer Tsang

Gene therapies have tremendous potential in treating a variety of diseases, but ones that use adeno-associated viruses (AAV) as their delivery vehicle are often too small to deliver a full human gene. While there have been many attempts at using multiple AAVs to deliver gene fragments into the cell where they can assemble together once inside, these efforts often proved inefficient.
First brain-delivered AAV therapy approved by FDA

Feb 3, 2025 | drugdiscoverynews.com | Jennifer Tsang

Until recently, the rare genetic disease, aromatic L-amino acid decarboxylase (AADC) deficiency, had no cure. The disease, which begins in the first months after birth, affects physical, mental, and behavioral aspects of life, and treatment has mainly targeted symptoms. Things are changing, however, with the introduction of new gene therapies that attack the disease at its source. On November 13, 2024, the Food and Drug Administration (FDA) to treat AADC deficiency in children and adults.
Future-proofing potato crops to resist heat waves

Jan 16, 2025 | advancedsciencenews.com | Jennifer Tsang

Ensuring access to food is becoming more difficult in many parts of the world due, in large part, to the effects of climate change. Crop yields have plateaued in recent years and rising temperatures can make it more difficult for crops to thrive. To overcome these challenges, scientists from the University of Illinois sought to “future proof” potatoes to resist the effects of climate change and boost crop yields amidst rising temperatures.
The surprising link between saliva and stress during pregnancy

Dec 26, 2024 | advancedsciencenews.com | Jennifer Tsang

Scientists find unique combinations of oral microbes can help identify states of stress in pregnant individuals. What can our spit tell us about our mental health? Quite a bit actually.