Jeremy Bjelajac

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Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche - Nature Communications

May 10, 2023 | nature.com | Daniel Haensel |Bence Daniel |Tania Fabo |Jeremy Bjelajac |Nancy Li |Ansuman T. Satpathy | +2 more

AbstractCancer immunotherapies have revolutionized treatment but have shown limited success as single-agent therapies highlighting the need to understand the origin, assembly, and dynamics of heterogeneous tumor immune niches. Here, we use single-cell and imaging-based spatial analysis to elucidate three microenvironmental neighborhoods surrounding the heterogeneous basal cell carcinoma tumor epithelia.

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