Jeremy Hill

Sep 21, 2024 | biorxiv.org | Shenjian Ai |Joshua Liu |Jeremy Hill |Xiaoping Jiang

AbstractCentral nervous system (CNS) resident memory CD8 T cells (TRM) that express IFN-gamma contribute to neurodegenerative processes, including synapse loss, leading to memory impairments. Here, we show that CCR2 signalling in CD8 TRM that persist within the hippocampus after recovery from CNS infection with West Nile virus (WNV) significantly prevents the development of memory impairments.