Jerome Noailly

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Parallel Networks to simulate complex multicellular dynamics - A proof of concept with intervertebral disc cell systems

Aug 30, 2024 | biorxiv.org | Laura Baumgartner |Jerome Noailly |Pompeu Fabra

AbstractBackground: Network models are convenient to represent in a mechanistic way the complexity of cell biological activity. Dynamic simulations of such networks might require approximations of equation parameters through reverse engineering, numerous and costly experimental research, and/or have limited capacity to explore cell responses to chronic, dose-dependent stimulus exposure.
Parallel networks to predict TIMP and protease cell activity of Nucleus Pulposus cells exposed and not exposed to pro-inflammatory cytokines

Aug 28, 2024 | biorxiv.org | Laura Baumgartner |Jerome Noailly |Universitat Pompeu Fabra |Sandra Witta

AbstractBackground: Intervertebral disc (IVD) degeneration is characterized by a disruption of the balance between anabolic and catabolic cellular processes. Within the Nucleus Pulposus (NP), this involves increased levels of the pro-inflammatory cytokines Interleukin 1beta (IL1B) and Tumor Necrosis Factor (TNF) and an upregulation of the protease families MMP and ADAMTS. Primary inhibitors of those proteases are the tissue inhibitors of matrix metalloproteinases (TIMP).

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