Jessica Medina

1 month ago | nature.com | Olivier Salamin |Justin Carrard |Jessica Medina |Raul Nicoli |Tiia Kuuranne |Nelly Pitteloud | +5 more

The impact of testosterone administration on the circulating lipidome in females remains unexplored, despite its relevance to understanding metabolic disorders like polycystic ovary syndrome (PCOS). This study addresses this gap by examining the effects of testosterone gel on the plasma lipidome of healthy women over three menstrual cycles. A cohort of 14 women aged 22–37 years with regular cycles was analyzed, with plasma samples collected at baseline, during peak testosterone levels (D45), and post-treatment (D59, D80). Testosterone gel treatment lasted 28 days, administered between day 29 and day 57 of the study. Using a deep-targeted lipidomic approach, 597 lipids were quantified to provide a detailed profile of the lipidome and capture subtle changes in lipid species and their associations with testosterone fluctuations. Extensive profiling revealed a significant decrease in 17 lipid species, especially ether- and ester-linked lysophosphatidylcholines (LPC), at peak testosterone. These lipid reductions were strongly negatively correlated with free and total testosterone, as well as dihydrotestosterone (DHT), and positively correlated with SHBG levels. Notably, intra-individual lipid variability was consistently lower than inter-individual variability, indicating a highly personalized lipidome regulation. Despite testosterone-induced changes, overall plasma lipidome alterations were minimal, suggesting mechanisms that maintain lipid homeostasis. This study highlights the complex interplay between testosterone and lipid metabolism in women. The minimal overall lipidome changes and high inter-individual variability point to the need for further research to assess the clinical relevance of these findings, particularly in hyperandrogenic conditions like PCOS. Clinical Trial Registration number: This study was registered on https://www.isrctn.com/ (ISRCTN10122130) on 09/01/2019.

Dec 2, 2024 | mdpi.com | James Allen |Xiaojian Zhang |Jessica Medina |Matthew Thomas

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Mar 11, 2024 | valencia.elperiodicodeaqui.com | Jessica Medina

Un dels camps de cítrics a la Comarca de la Safor./ EPDAEn la comarca de la Safor, són diversos els factors que afecten la productivitat del sector agrícola, com la falta de rendibilitat, el canvi climàtic, les plagues, escalada dels costos de producció, i falta d’ajudes per a pal·liar la sequera, són alguns dels problemes als quals s’enfronten els agricultors cada dia.

Mar 8, 2024 | valencia.elperiodicodeaqui.com | Jessica Medina

Taller de xapes igualitàries / EPDALes activitats al mes de març van començar a l'Ajuntament amb la tradicional Crida. Seguidament, el dilluns 4 de març i amb motiu de la Setmana de la Dona, va tindre  lloc a la Càmara Agrària a partir de les 17:30 hores, el taller de xapes igualitàries, impartit per les professionals de Proactives i dirigit a tots els públics. Els assistents han pogut confeccionar les seues xapes i personalitzar-les amb missatges en homenatge a les dones.

Mar 7, 2024 | valencia.elperiodicodeaqui.com | Jessica Medina

Paqui Monparler, presidenta de la Mancomunitat de la Ribera Alta. / EPDA Imatge a les institucions europees amb la junta de govern. / EPDAPaqui Monparler, alcaldessa de Senyera i ara presidenta de la Mancomunitat de la Ribera Alta, va ser regidora  d'Educació de 1995 a 2002, centrada en millorar els serveis educatius municipals, com ara l'escoleta infantil, el menjador, la biblioteca, el col·legi públic, etc.