Jesus Alegre-Díaz

Dec 5, 2024 | digitalcommons.library.tmc.edu | Christina Magnussen |Francisco Ojeda |Darryl Leong |Jesus Alegre-Díaz

BACKGROUND: Five modifiable risk factors are associated with cardiovascular disease (CVD) and all-cause mortality. The regional and sex-specific prevalence of these modifiable risk factors and their impact on CVD and all-cause mortality have not been evaluated using individual-level data. METHODS: The Global Cardiovascular Risk Consortium harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions.

Oct 11, 2023 | nature.com | Jason Torres |Jesus Alegre-Díaz |Joshua Backman |Joelle Mbatchou |Michael Turner |Yuxin Zou | +18 more

AbstractThe Mexico City Prospective Study is a prospective cohort of more than 150,000 adults recruited two decades ago from the urban districts of Coyoacán and Iztapalapa in Mexico City1. Here we generated genotype and exome-sequencing data for all individuals and whole-genome sequencing data for 9,950 selected individuals. We describe high levels of relatedness and substantial heterogeneity in ancestry composition across individuals.

Aug 26, 2023 | nejm.org | Christina Magnussen |Francisco Ojeda |Darryl Leong |Jesus Alegre-Díaz

October 5, 2023N Engl J Med 2023; 389:1273-1285 DOI: 10.1056/NEJMoa2206916 AbstractFive modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.