Ji-Ung Jung

Jun 27, 2024 | biorxiv.org | Clinton A. Taylor |Ji-Ung Jung |Justin Li |Sachith Gallolu Kankanamalage

AbstractThe WNK-OSR1/SPAK protein kinase signaling pathway regulates ion homeostasis and cell volume, but its other functions are poorly understood. To uncover undefined signaling functions of the pathway we analyzed the binding specificity of the conserved C-terminal (CCT) domains of OSR1 and SPAK to find all possible interaction motifs in human proteins. These kinases bind the core consensus sequences R-F-x-V/I and R-x-F-x-V/I.