Jiacheng Ding

Apr 5, 2024 | elifesciences.org | Maria L Adelus |Jiacheng Ding |Binh Tran |Bình Trần |Austin C Conklin

eLife assessment This is a fundamental resource of snRNA-seq and chromatin accessibility data from human aortic endothelial cells (ECs), treated with relevant perturbations such as IL1b, TGFB2, or siERG. The authors show that ECs can be categorized by distinct subpopulations of differing plasticity.

Aug 10, 2023 | biorxiv.org | Binh Tran |Bình Trần |Maria L Adelus |Jiacheng Ding |Austin C Conklin

AbstractObjective: Endothelial cells (ECs) are a major cell type in atherosclerosis progression, and heterogeneity in EC sub-phenotypes are becoming increasingly appreciated. Still, studies quantifying EC heterogeneity across whole transcriptomes and epigenomes in both in vitro and in vivo models are lacking.