Jiajia Ma

1 week ago | journals.plos.org | Jiajia Ma |Nanyang Technological |Tom Carney

Loading metrics Open Access Peer-reviewedResearch Article Citation: Ma J, Carney TJ (2025) Protease-mediated activation of Par2 elicits calcium waves during zebrafish egg activation and blastomere cleavage. PLoS Biol 23(6): e3003181. https://doi.org/10.1371/journal.pbio.3003181Academic Editor: Carmen J.

May 14, 2024 | biorxiv.org | Jiajia Ma |Tom Carney |Nanyang Technological

AbstractSuccessful initiation of animal development requires activation of the egg immediately prior to fusion of gamete pronucleii. In all taxa, this is initiated by waves of calcium transients which transverse across the egg. Calcium waves also occur at cleavage furrows during later blastula cytokinesis. Calcium is released from the endoplasmic reticulum through activation of 1,4,5-trisphosphate (IP3) receptors.