Jianxun Wang

Aug 20, 2024 | mdpi.com | Yan Gao |Jianxun Wang |Wenhao Yu |Lu Yi

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Jun 7, 2024 | nature.com | Jianxun Wang

AbstractThe response of cardiac fibroblast proliferation to detrimental stimuli is one of the main pathological factors causing heart remodeling. Reactive oxygen species (ROS) mediate the proliferation of cardiac fibroblasts. However, the exact molecular mechanism remains unclear. In vivo, we examined the oxidative modification of miRNAs with miRNA immunoprecipitation with O8G in animal models of cardiac fibrosis induced by Ang II injection or ischemia‒reperfusion injury.