Jiawei Zhong

Sep 12, 2024 | nature.com | Shuyao Zhang |Yuhua Xiao |Xu Chen |Jiawei Zhong |Xu Liu |Yuanhui Qiu | +6 more

AbstractSingle-cell multi-omics sequencing is a powerful approach to analyze complex mechanisms underlying neuronal development and regeneration. However, current methods lack the ability to simultaneously profile RNA alternative splicing and chromatin accessibility at the single-cell level. We develop a technique, single-cell RNA isoform and chromatin accessibility sequencing (scRICA-seq), which demonstrates higher sensitivity and cost-effectiveness compared to existing methods.