JieFu Li

Oct 13, 2024 | biorxiv.org | Hanwen Zhou |Yue Hu |Yulong Zheng |JieFu Li

AbstractRNAs are widely regulated in cellular processes by their cis-regulatory elements and trans-acting RNA binding proteins, the information of which is encoded in RNA sequences spanning evolutionary diversity. Deciphering the rules underlying RNA regulation can provide new insights into molecular mechanisms and RNA therapies. The large language models have demonstrated their efficacy in the analysis of human languages and protein sequences.

Mar 28, 2024 | academic.oup.com | JieFu Li |Ziyuan Wang

Protein sequence database search and multiple sequence alignment (MSA) generation is a fundamental task in many bioinformatics analyses. As the data volume of sequences continues to grow rapidly, there is an increasing need for efficient and scalable multiple sequence query algorithms for super-large databases without expensive time and computational costs.