Jieying Li

Jan 12, 2024 | onlinelibrary.wiley.com | Yuanyuan Luo |Jun Xiao |Jieying Li

1 INTRODUCTION Recent studies describing patients with autoantibodies against IgLON5, a neuronal cell-adhesion protein, revealed a distinctive sleep disorder, obstructive sleep apnea, gait instability, movement disorders, and brainstem involvement.1, 2 Neuropathological examination demonstrated accumulation of abnormal hyperphosphorylated tau proteins, including 3R and 4R tau isoforms, and neuronal tau deposits in the hypothalamus, the prehypothalamic region, and the tegmentum of the...