Jieying Pan

Jul 23, 2024 | cell.com | Yu Yang |Xueyan Chen |Huiheng Ning |Jieying Pan

Highlights • A pan-cancer single-cell atlas of tumor-infiltrating B cells (TIBs) is constructed • Abundance and subtype composition of TIBs exhibit heterogeneity across 19 cancer types • Tumor-associated atypical B cells (TAABs) are associated with favorable prognosis • TAABs are clonally expanded and activated, appearing to interact with CD4 T cells Summary Characterizing the compositional and phenotypic characteristics of tumor-infiltrating B cells (TIBs) is important for advancing our...