Jin-Soo Kim

Nov 29, 2024 | nature.com | Jin-Soo Kim |Hanna Lee |Jerry Tjiputra |Jin-Ho Yoon

replying to W.R. Lee et al. Communications Earth & Environment https://doi.org/10.1038/s43247-024-01881-y (2024)In our original contribution, we demonstrated using an Earth system model that the Arctic extreme temperatures rise under three radiative forcing geoengineering methods to mitigate the global mean temperature1.

Sep 26, 2024 | nature.com | Jin-Soo Kim

AbstractCRISPR-free, protein-only cytosine base editors (CBEs) or adenine base editors, composed of DNA-binding proteins such as zinc finger proteins or transcription activator-like effectors (TALEs) and nucleobase cytosine or adenine deaminases, respectively, enable organellar DNA editing in cultured cells, animals and plants1,2,3,4.

Apr 4, 2024 | nature.com | Jin-Soo Kim |Hanna Lee |Jerry Tjiputra |Jin-Ho Yoon |Rhonda C. Müller

AbstractRadiative forcing geoengineering is discussed as an intermediate solution to partially offset greenhouse gas-driven warming by altering the Earth’s energy budget.

Sep 5, 2023 | biorxiv.org | Jin-Soo Kim

AbstractDddA-derived cytosine base editors (DdCBEs) and transcription activator-like effector (TALE)-linked deaminases (TALEDs) catalyze targeted base editing of mitochondrial DNA (mtDNA) in eukaryotic cells, a method useful for modeling of mitochondrial genetic disorders and developing novel therapeutic modalities. Here, we report that A-to-G editing TALEDs but not C-to-T editing DdCBEs induce tens of thousands of transcriptome-wide off-target edits in human cells.