Jingnan Shen

Sep 24, 2023 | mdpi.com | Pengyu Chen |Jingnan Shen

1. IntroductionOsteosarcoma (OS) is a formidable malignant neoplasm that predominantly affects adolescents during periods of rapid growth. Its genesis is commonly traced to the epiphysis of long bones, and it often portends a bleak prognosis. Without intervention, OS can lead to severe disability. Alarmingly, recurrence and metastasis, especially to the lungs, are not uncommon, further complicating the prognosis [,].