Jingyi Cai

Oct 28, 2024 | biorxiv.org | Jingyi Cai |Jiayu Liu |fan wei |Wenqi Xu

AbstractIndustrial microorganisms often face challenges in utilizing renewable substrates such as methanol, formate, and xylose. We present findings that the proportion of biomass precursors that must be synthesized from unadapted carbon sources is a critical determinant of the evolutionary driving force and minimal substrate requirements, using a new computational framework, AdaptUC. We predict metabolic engineering strategies for Adaptive Laboratory Evolution (ALE).