Jingying Chen

Jan 8, 2025 | nature.com | Jianbo He |Jingying Chen

AbstractSevere damage to the intrahepatic biliary duct (IHBD) network occurs in multiple human advanced cholangiopathies, such as primary sclerosing cholangitis, biliary atresia and end-stage primary biliary cholangitis. Whether and how a severely damaged IHBD network could reconstruct has remained unclear.

Jul 15, 2024 | nature.com | Jingying Chen

AbstractIn zebrafish, brain lymphatic endothelial cells (BLECs) are essential for meningeal angiogenesis and cerebrovascular regeneration. Although epidermal growth factor-like domain 7 (Egfl7) has been reported to act as a pro-angiogenic factor, its roles in lymphangiogenesis remain unclear. Here, we show that Egfl7 is expressed in both blood and lymphatic endothelial cells. We generate an egfl7 cq180 mutant with a 13-bp-deletion in exon 3 leading to reduced expression of Egfl7.

May 1, 2024 | mdpi.com | Hongyu Zhao |Jingying Chen |Xiaofan Yang |Mingwei Zhuang

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