Jinlian Cao

Oct 28, 2024 | nature.com | Xiaosheng Yan |Jinlian Cao |Zexing Cao |Yirong Mo

AbstractEnantioselective synthesis governed by chiral catalysts has been extensively developed, but that without any chiral auxiliaries or chiral catalysts is rare, particularly when remote stereogenic centers are involved. Here we report an enantioselectivity of heterochiral coupling in the one-pot reaction of racemic hydrazides with achiral 1,4-bis(isothiocyanine)benzene, yielding preferentially the heterochiral bilateral azapeptides over the homochiral ones.