Joanna Crawford

Sep 11, 2023 | nature.com | Nicholas Matigian |Joanna Crawford |Helen Healy |Arti M. Raghubar

AbstractPerioperative immune checkpoint inhibitor (ICI) trials for intermediate high-risk clear cell renal cell carcinoma (ccRCC) have failed to consistently demonstrate improved patient outcomes. These unsuccessful ICI trials suggest that the tumour infiltrating immunophenotypes, termed here as the immune cell types, states and their spatial location within the tumour microenvironment (TME), were unfavourable for ICI treatment.

Jun 28, 2023 | mdpi.com | Sally Mortlock |Sohye Yoon |Joanna Crawford |Sushma Marla

3. Results 3.1. Comparing Quality of the Commercial and In-House CAGE Sequencing Protocols Raw tag counts were normalised to quantify the expression from each individual TSS and to enable comparison between multiple samples. Tag counts ranged from 10–20 million for the commercial protocol and 5–9 million for the in-house protocol (Table 2).