Jodie Hay

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Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells - Nature Communications

Jul 10, 2024 | nature.com | Hannah Donnelly |Rio Hermantara |Karen Dunn |Jodie Hay |Helen Wheadon |Alison M. Michie | +3 more

AbstractLong-term reconstituting haematopoietic stem cells (LT-HSCs) are used to treat blood disorders via stem cell transplantation. The very low abundance of LT-HSCs and their rapid differentiation during in vitro culture hinders their clinical utility.

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