Johan Geiser

Nov 30, 2024 | biorxiv.org | Stephane Hausmann |Johan Geiser |George Allen |Diego Gonzalez |Diego González

AbstractThe RNA degradosome is a bacterial multi-protein complex mediating mRNA processing and degradation. In Pseudomonadota, this complex assembles on the C-terminal domain (CTD) of RNase E through short linear motifs (SLiMs) that determine its composition and functionality. In the human pathogen Pseudomonas aeruginosa, the RNase E CTD exhibits limited similarity to that of model organisms, impeding our understanding of RNA metabolic processes in this bacterium.

Oct 16, 2024 | biorxiv.org | Stephane Hausmann |Johan Geiser |George Allen |Diego Gonzalez |Diego González

AbstractThe RNA degradosome, a multi-protein complex regulating mRNA in bacteria, assembles on the RNase E C-terminal domain (CTD) in Pseudomonadota (Proteobacteria) via short linear motifs (SLiMs). The composition of the Pseudomonas aeruginosa RNA degradosome is largely unknown, and its RNase E CTD shows limited similarity to those in models like Escherichia coli or Caulobacter crescentus. Our study characterizes the function of conserved SLiMs in P.