Johannes Hevler

Aug 25, 2023 | cell.com | Johannes Hevler |Biomolecular Mass Spectrometry |Roberta Filograna

Highlights • Three amino acids (EED) in UQCRC1 of complex III2 control respirasome stability • Homozygous Uqcrc1delEED knockin mice have drastically reduced respirasome levels • Profound depletion of respirasomes does not impair oxidative phosphorylation • Mice with a profound depletion of respirasomes have apparently normal physiology Summary The mammalian respiratory chain complexes I, III2, and IV (CI, CIII2, and CIV) are critical for cellular bioenergetics and form a stable assembly, the...