Johannes Sulzer

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Proton-pump inhibitors increase C. difficile infection risk by altering pH rather than by affecting the gut microbiome based on a bioreactor model

Jul 10, 2024 | biorxiv.org | Julia Schumacher |Patrick Mueller |Franziska Faber |Johannes Sulzer

AbstractClostridioides difficile infections often occur after antibiotic use, but they have also been linked to proton-pump inhibitor (PPI) therapy. The underlying mechanism — whether infection risk is due to a direct effect of PPIs on the gut microbiome or changes in gastrointestinal pH — has remained unclear.

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