John F. Fullard

Dec 9, 2024 | nature.com | Georgios Voloudakis |Karen Therrien |Simone Tomasi |Veera M. Rajagopal |Ditte Demontis |John F. Fullard | +3 more

AbstractPolygenic scores (PGS) enable the exploration of pleiotropic effects and genomic dissection of complex traits. Here, in 421,889 individuals with European ancestry from the Million Veteran Program and UK Biobank, we examine how PGS of 17 neuropsychiatric traits are related to membership in 22 broad professional categories.

Feb 22, 2023 | alz-journals.onlinelibrary.wiley.com | Minghui Wang |Lei Guo |John F. Fullard |Erming Wang

2.5 DMR-associated genes and AD risk genes After determining the methylomic contributions to gene and protein expression, we investigated correlations between individual DMRs and gene or protein expression. A gene was correlated with a DMR if it was significantly correlated with the DMR at a Benjamini–Hochberg (BH)-adjusted P-value < 0.05. We took the union of all the genes with significant positive correlations with a given DMR as the DMR-positively associated gene signature (PAS) for that DMR.