John Finlay

Dec 25, 2024 | cell.com | Jessica Waibl Polania |Alexandra M Hoyt-Miggelbrink |William H. Tomaszewski |Lucas P Wachsmuth |Selena J. Lorrey |Daniel Wilkinson | +5 more

Keywords T cell exhaustion tumor-associated macrophage tumor microenvironment tumor immunology immunotherapy brain tumor brain metastasis glioblastoma Introduction Brain tumors, both primary and metastatic, continue to herald poor survival.1,2 Immunotherapies, such as immune checkpoint blockade (ICB) and chimeric antigen receptor (CAR) T cells, hold promise for improving outcomes but remain only marginally effective within the intracranial confines.3,4 This has been especially true in the...

Dec 13, 2023 | dialnet.unirioja.es | John Finlay

Hybrid encounters: Refraiming Picasso´s Suite Vollard[1]Independent Picasso ScholarLocalización: Eviterna, ISSN-e 2530-6014, Nº. 14 (Septiembre), 2023 (Ejemplar dedicado a: ¿Aún interesa Picasso? Revisiones, perspectivas y proyecciones), págs. 51-69Idioma: inglésTítulos paralelos: Encuentros híbridos: Reencuadrando la Suite Vollard de PicassoEnlacesTexto completoResumenespañolEl 50º aniversario de la muerte de Picasso brinda la oportunidad de revisar su enfoque del arte.

Nov 5, 2023 | biorxiv.org | Selena J. Lorrey |Lucas P Wachsmuth |John Finlay |Jessica Waibl Polania

AbstractIntracranial tumors present unique challenges for immunotherapy, which can include both local and systemic immune suppression whose mechanistic underpinnings are incompletely understood. Here, we reveal that tumors harbored intracranially elicit systemic increases in catecholamines and chronic sympathetic hyperactivity that drives T cell dysfunction and limits immunotherapeutic success.