
John J. Cush
Founder and Executive Editor at RheumNow
Know-it-Now. Info on RA, Stills disease, Lupus, Gout, Pregnancy, Spondylitis, Psoriasis, Drug Safety, Rheumatology Research, Medical Education & Drug Evaluation
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Feb 29, 2024 |
healio.com | John J. Cush |Michael E Weinblatt |Arthur Kavanaugh
IntroductionThe discovery and introduction of corticosteroid therapy by Philip Hench in the late 1940s and early 1950s was a seminal advance in the treatment of inflammatory diseases, including rheumatoid arthritis (RA). Prior to the introduction of steroids, RA therapy was dominated by poorly effective and toxic therapies (aspirin and gold salts). The glucocorticoid compounds became well known for their impressive and rapid clinical efficacy in a variety of inflammatory clinical disorders.
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Telitacicept, recombinant fusion protein targeting BLyS & APRIL, studied in 41 Chinese SLE pts (added to standard Rx) showed mean improvements in SLEDAI-2K (10.0 to 6.25 @12 wks & 4.2 @24 wks;p<.001), daily prednisone (21 mg to 9.8mg) & proteinuria (2.8 gr to 1.3 gr/day) https://t.co/xtPMSZBoWg

National Inpatient Sample retrospective study of #RA pts using cannabis (n 42,415). Cannabis assoc w/ lower mortality (0.98% vs 2.71%; OR 0.50), depression (OR 0.47), chronic pain (OR 0.45), anxiety (OR 0.55); but more use of opioids (OR: 1.10), nicotine (OR: 1.35), & alcohol https://t.co/qzlj0MIClY

Vitamin D Headlines (5.9.2025) Dr. Jack Cush reviews the news, journal reports and lupus highlights from the past week on RheumNow. Triple positivity, the gut and CRPS, and hope for better outcomes with Vitamin D therapy. https://t.co/i9OJrYR59T https://t.co/PQ3fAR5teR