John Quinlan

Apr 23, 2024 | committees.parliament.uk | Andrew Neil |James Harding |John Quinlan |Tom Slater

Andrew Neil and other media executives give evidence on future of newsThe Communications and Digital Committee takes evidence from Andrew Neil, Chairman of the Spectator, and other media executives as it continues its inquiry into the future of news.

Oct 23, 2023 | biorxiv.org | John Quinlan |Robert W. Robey |Joanna Thomas |Collin T. Inglut

AbstractATP-binding cassette (ABC) transporters expressed at the blood-brain barrier (BBB) impede delivery of therapeutic agents to the brain, including agents to treat neurodegenerative diseases and primary and metastatic brain cancers. Two transporters, P-glycoprotein (P-gp, ABCB1) and ABCG2, are highly expressed at the BBB and are responsible for the efflux of numerous clinically useful chemotherapeutic agents, including irinotecan, paclitaxel, and doxorubicin.