John Tuddenham

Oct 15, 2024 | nature.com | John Tuddenham |Anthony Khairallah |Bradley T. Hyman |Sarah C. Hopp |Naomi Habib |Hans-Ulrich Klein | +5 more

AbstractHuman microglia play a pivotal role in neurological diseases, but we still have an incomplete understanding of microglial heterogeneity, which limits the development of targeted therapies directly modulating their state or function. Here, we use single-cell RNA sequencing to profile 215,680 live human microglia from 74 donors across diverse neurological diseases and CNS regions.