John Widloski

Jul 21, 2024 | biorxiv.org | Caitlin S. Mallory |John Widloski |David Foster

AbstractSpontaneous neural activity sequences are generated by the brain in the absence of external input, yet how they are produced remains unknown. During immobility, hippocampal replay sequences depict spatial paths related to the animal's past experience or predicted future.

Jun 10, 2024 | biorxiv.org | John Widloski |David Foster

AbstractSpatial sequences encoded by cells in the hippocampal-entorhinal region have been observed to spontaneously alternate across the animal's midline during navigation in the open field, but it is unknown how this occurs. We show that sinusoidal sampling patterns emerge rapidly and robustly in a simple model of the hippocampus that makes no assumptions about sequence direction. We corroborate our findings using hippocampal data from rats navigating in the open field.

May 14, 2024 | biorxiv.org | John Widloski |David Foster

AbstractSharp-wave ripples in the hippocampus are believed to be a fundamental mechanism for the consolidation of episodic memories. During ripples, hippocampal neurons are re-activated in sequences called replay, which have been hypothesized to reflect episodic memory content. Ripples and replay are usually reported to co-occur, and are commonly thought to reflect the same process.