John Yu

La Jolla

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Articles

Priming of macrophage by glycosphingolipids from extracellular vesicles facilitates immune tolerance for embryo-maternal crosstalk

Oct 23, 2023 | cell.com | Alice Yu |Chang Gung |John Yu

Highlights•GSLs are incorporated into macrophages via EVs derived from human embryonic stem cells•GSLs in macrophages promote TREM2-mediated phagocytic activity•GSLs in macrophages could be further delivered to T cells and suppress proliferation•GSLs in macrophages enhance the ability of trophoblasts for invasionSummaryGlycosphingolipids (GSLs) display diverse functions during embryonic development.

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