Jon Clardy

Jul 23, 2024 | pubs.acs.org | Ziyang Zheng |Jon Clardy |Hung-Wen Liu |W. David

IntroductionClick to copy section linkSection link copied!Aerocyanidin (1), (1) YM-47515 (2) (2) and amycomicin (3) (3) isolated from Chromobacterium violaceum, Micromonospora echinospora and Amycolatopsis sp. AA4, respectively, are the only three long-chain fatty acid derivatives featuring a γ-hydroxyl-α,β-epoxy isonitrile functionality (Figure 1A).

May 10, 2024 | dx.doi.org | Ziyang Zheng |Jon Clardy |Hung-Wen Liu

Nov 15, 2023 | nature.com | Emerson Glassey |Jon Clardy

AbstractHuman-associated bacteria secrete modified peptides to control host physiology and remodel the microbiota species composition. Here we scanned 2,229 Human Microbiome Project genomes of species colonizing skin, gastrointestinal tract, urogenital tract, mouth and trachea for gene clusters encoding RiPPs (ribosomally synthesized and post-translationally modified peptides). We found 218 lanthipeptides and 25 lasso peptides, 70 of which were synthesized and expressed in E.

Feb 8, 2023 | cell.com | Eric Brown |Jon Clardy |Ramnik Xavier

Koppel N. Maini Rekdal V.M. Balskus E.P. Chemical transformation of xenobiotics by the human gut microbiota. Science. 2017; 356: 1246-1257Eichelmann F. Sellem L. Wittenbecher C. Jäger S. Kuxhaus O. Prada M. Cuadrat R. Jackson K.G. Lovegrove J.A. Schulze M.B. Deep lipidomics in human plasma: cardiometabolic disease risk and effect of dietary fat modulation. Circulation. 2022; 146: 21-35Lamichhane S. Sen P. Alves M.A. Ribeiro H.C. Raunioniemi P. Hyötyläinen T. Orešič M.