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Nov 22, 2024 | 
biorxiv.org | Patrick Madden |Ester Marina-Zárate |Kristen A. Rodrigues |Jon M. Steichen
AbstractRare B cells can have special pathogen-recognition features giving them the potential to make outsized contributions to protective immunity. However, rare naive B cells infrequently participate in immune responses. We investigated how germline-targeting vaccine antigen delivery and adjuvant selection affect priming of exceptionally rare BG18-like HIV broadly neutralizing antibody-precursor B cells (~1 in 50 million) in non-human primates.
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May 16, 2024 | 
science.org | Jon M. Steichen |Zhenfei Xie |Felix Strieth-Kalthoff |Jiankun Lyu
Research ArticleJiankun Lyu https://orcid.org/0000-0002-0461-5454 [email protected], Nicholas Kapolka https://orcid.org/0000-0003-2223-8207, [...] , Ryan Gumpper, Assaf Alon https://orcid.org/0000-0001-8102-5290, [...] , Liang Wang https://orcid.org/0000-0002-8868-8449, Manish K.
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May 16, 2024 | 
science.org | Jon M. Steichen |Zhenfei Xie |Felix Strieth-Kalthoff |Tao Zhang
Research Article ORGANIC CHEMISTRY Tao Zhang https://orcid.org/0009-0002-1668-0453, Zi-Yu Zhang https://orcid.org/0009-0002-8542-8972, [...] , Guowei Kang https://orcid.org/0000-0002-8334-0339, Tao Sheng https://orcid.org/0000-0001-5339-9834, [...] , Jie-Lun Yan https://orcid.org/0000-0003-3340-2746, Yuan-Bin Yang https://orcid.org/0009-0000-6476-549X, Yuxin Ouyang https://orcid.org/0000-0001-5453-513X, and Jin-Quan Yu https://orcid.org/0000-0003-3560-5774 [email protected]+5 authors +3...
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May 16, 2024 | 
science.org | Jon M. Steichen |Zhenfei Xie |Felix Strieth-Kalthoff |Matthew Warren
Solar storm puts on stunning displaySpace WeatherAn aurora makes a rare appearance over the Bonneville Salt Flats in Utah. PHOTO: BLAKE BENARD/GETTY IMAGESOpen in viewerOn the night of 10 May, Earth’s magnetic field got walloped by the Sun, as the planet experienced its most extreme geomagnetic storm since 2003.
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May 16, 2024 | 
science.org | Jon M. Steichen |Zhenfei Xie |Felix Strieth-Kalthoff |Chris J Law
Research ArticleADAPTIVE TOOL USEChris J. Law https://orcid.org/0000-0003-1575-7746 [email protected], M. Tim Tinker https://orcid.org/0000-0002-3314-839X, [...] , Jessica A. Fujii https://orcid.org/0000-0003-4794-479X, Teri Nicholson https://orcid.org/0000-0002-9895-1458, [...] , Michelle Staedler https://orcid.org/0000-0002-1101-6580, Joseph A. Tomoleoni https://orcid.org/0000-0001-6980-251X, Colleen Young https://orcid.org/0000-0001-9604-884X, and Rita S.
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May 16, 2024 | 
science.org | Jon M. Steichen |Zhenfei Xie |Felix Strieth-Kalthoff |Chad A. Mirkin
Chad A. Mirkin [email protected], Edward H. Sargent [email protected], and Daniel P. Schrag [email protected] Info & AffiliationsThe decreasing cost of electricity worldwide from wind and solar energy, as well as that of end-use technologies such as electric vehicles, reflect substantial progress made toward replacing fossil fuels with alternative energy sources. But a full transition to clean energy can only be realized if numerous challenges are overcome.
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May 16, 2024 | 
science.org | Jon M. Steichen |Zhenfei Xie |Felix Strieth-Kalthoff
A network of automated labs discovered a compound that emits blue laser light with record efficiency. Who needs scientists anyway? A global consortium of six automated laboratories, overseen by artificial intelligence (AI), set out to produce new laser materials, dividing the labor from synthesis to testing. The effort yielded a compound that emits laser light with record-setting efficiency, researchers report on p. 756.
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May 16, 2024 | 
science.org | Jon M. Steichen |Zhenfei Xie |Felix Strieth-Kalthoff |Ankit Walia
Plant Science Protein degradation and cell expansionAnkit WaliaAs seedlings emerge through soil, an apical hook forms to protect delicate tissues. PHOTO: MATTHEW NOBLE HORTICULTURAL/ALAMY STOCK PHOTOThe plant hormone auxin regulates differential cell expansion. As seedlings begin to navigate through soil after germination, an apical hook is formed by bending of the upper hypocotyl that protects the fragile shoot meristem.
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May 16, 2024 | 
science.org | Jon M. Steichen |Zhenfei Xie |Felix Strieth-Kalthoff |Richard Stone
Thomas Müller displays his artwork, some of which was inspired by his experience with psychosis brought on by autoimmune encephalitis. Open in viewerTHOMAS MÜLLER* ONCE ENJOYED a serene life as a psychiatrist with his wife and three children in Lahr, a German town near the French border. He was also a talented artist who loved painting with his kids, and a voracious reader fond of the speculative science fiction of Philip K. Dick and the eldritch tales of H. P. Lovecraft.
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May 16, 2024 | 
science.org | Jon M. Steichen |Zhenfei Xie |Felix Strieth-Kalthoff |Dustin Thoman
Dustin B. Thoman [email protected], Jessi L. Smith, [...] , Ivan A. Hernandez, Christal D. Sohl, and Miguel T. Villodas+2 authors fewerAuthors Info & AffiliationsBiochemist Christal Sohl (right) interacts with trainees Isaac Marquez (left) and Mowaffaq Adam (center) in her lab at San Diego State University.
