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3 weeks ago | 
contemporarypediatrics.com | Marian Freedman |Jon Matthew Farber
Published in Journal of Pediatric Gastroenterology and NutritionIn the wake of the no-biopsy approach to diagnosing celiac disease (CD) introduced in the 2012 European Society for Paediatric Gastroenterology and Hepatology and Nutrition guidelines, Israeli investigators demonstrated that a repeated anti–tissue transglutaminase-2 (anti-TG2) test could replace the antiendomysial antibody (EMA) test required by the guidelines as the confirmatory serology test for diagnosing CD.
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4 weeks ago | 
contemporarypediatrics.com | Marian Freedman |Jon Matthew Farber
Published in Acta PaediatricaHow should a positive viral test result influence the management of young infants who have been hospitalized for fever? One proposal comes from a study in a single children’s hospital, where all febrile infants are admitted to a dedicated infectious diseases unit and are tested for respiratory viruses, herpes simplex virus, enterovirus, and parechovirus, then given 24 hours of antibiotic treatment if found to have a viral infection and no growth on bacterial culture.
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Feb 4, 2025 | 
contemporarypediatrics.com | Marian Freedman |Jon Matthew Farber
Analysis of data for infants who underwent esophageal atresia and tracheoesophageal fistula (EA/TEF) repair suggest that the use of intravenous (IV) acetaminophen along with opioids (IV APAP) instead of opioids alone is associated with a longer length of stay (LOS) but decreased daily costs and mortality.
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Jan 29, 2025 | 
contemporarypediatrics.com | Marian Freedman |Jon Matthew Farber
A retrospective review of electronic health records of children with attention-deficit/hyperactivity disorder (ADHD) without autism spectrum disorder (ADHD – ASD) and children with both ADHD and ASD (ADHD + ASD) found that for children with ADHD – ASD, stimulant medications were significantly more effective than α2 agonist (α2A) medications. For those with ADHD + ASD, however, stimulants and α2As had similar effectiveness.
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Oct 15, 2024 | 
contemporarypediatrics.com | Jon Matthew Farber
A retrospective study in 36 children with Lennox-Gastaut syndrome (LGS), Dravet syndrome (DS), or another drug-resistant epilepsy (DRE) found that cannabidiol treatment reduced seizure frequency in two-thirds of patients and was not associated with adverse effects.
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Oct 14, 2024 | 
contemporarypediatrics.com | Marian Freedman |Jon Matthew Farber
To determine parents’ preferences and motivations for receiving and discussing prognostic genetic test results, Australian investigators conducted semistructured interviews with parents of children with neurodevelopmental conditions that are chronic and not life-limiting. The interviews, which were conducted over Zoom or via telephone or email, were with 32 parents of children with fragile X syndrome, DiGeorge syndrome, or Angelman syndrome.
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Oct 10, 2024 | 
contemporarypediatrics.com | Jon Matthew Farber
According to a recent study, the answer to this question is no. Investigators analyzed data from 144 studies of early childhood autism interventions related to more than 9038 children and found no significant association between intervention amounts and intervention effects. The mean age of participants was 49.3 months, and 82.6% were boys.
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Sep 5, 2024 | 
contemporarypediatrics.com | Marian Freedman |Jon Matthew Farber
Details A meta-analysis of 5 studies on the effect of lactase supplementation on infant colic found that the effectiveness of this treatment is still open to question. The analysis was based on 5 randomized controlled trials (RCTs) involving 391 infants aged from 23 days to 6 months who were diagnosed with infant colic and were treated orally with either lactase or a placebo for 7 days to 28 days.
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Sep 2, 2024 | 
contemporarypediatrics.com | Marian Freedman |Jon Matthew Farber
According to a meta-analysis, adding nebulized magnesium sulfate to standard medical therapy (SMT) does indeed lead to a small statistically significant improvement in treatment outcomes in children with asthma exacerbations compared with using SMT alone. However, the effect size of the differences is probably too small to be clinically relevant.
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Aug 30, 2024 | 
contemporarypediatrics.com | Marian Freedman |Jon Matthew Farber
Patients believe cold therapy helps alleviate pain after an appendectomy, a recent study found. Such therapy does not reduce the need for narcotics, however, according to the results of the randomized controlled trial. Investigators divided into 2 groups 58 patients aged at least 7 years who had undergone laparoscopic appendectomy. One group, ie, the treatment group, received cold therapy in addition to standard postoperative analgesia.
