Jonas Paludo

Aug 28, 2024 | nature.com | Saurabh Zanwar |Jonas Paludo |Ronald S. Go |Joselle M. Cook |Sikander Ailawadhi |Thomas M Habermann | +10 more

An under-recognized source of bleeding in Waldenström macroglobulinemia (WM) is the development of an acquired von Willebrand syndrome (AVWS) [1]. In WM, the von Willebrand Factor (vWF) glycoprotein can be degraded due to autoantibody destruction, increased shear stress due to hyperviscosity, or sequestered due to adsorption onto malignant cells, leading to the development of AVWS (AVWS-WM) [1, 2].

Aug 11, 2024 | nature.com | Razan Mohty |Radhika Bansal |Urshila Durani |Madiha Iqbal |Yucai Wang |Jonas Paludo | +8 more

Dear Editor,Hemophagocytic lymphohistiocytosis (HLH) is a rare complication of chimeric antigen receptor T-cell (CAR-T) therapy [1,2,3]. With the increasing use of CAR-T therapy in treating hematological malignancies, the unique phenomenon of CAR-T-associated HLH (carHLH) is increasingly recognized. Albeit rare, reported rates vary from 1–3% to 35% depending on the underlying disease, patient population and the CAR-T product [1,2,3].

Nov 12, 2023 | nature.com | Jennifer J. Gile |Matthew J. Maurer |Jonas Paludo |Stephen Ansell |Thomas M Habermann |Thomas E Witzig | +4 more

AbstractOver the last two decades, the frontline therapy for mantle cell lymphoma (MCL) has evolved. However, the impact of subsequent lines of therapy on survival outcomes has not been well characterized. In this study, we investigated the treatment patterns and survival outcomes in patients with relapsed/refractory (R/R) MCL treated with second-line (2 L) therapy. Adult patients with newly diagnosed MCL from 2002 to 2015 were enrolled in a prospective cohort study.

Aug 17, 2023 | nature.com | William Breen |Jason Young |Radhika Bansal |N. Nora Bennani |Jonas Paludo |Yucai Wang | +2 more

AbstractPET/CT is used to evaluate relapsed/refractory non-Hodgkin lymphoma (NHL) prior to chimeric antigen receptor T-cell (CAR-T) infusion at two time points: pre-leukapheresis (pre-leuk) and pre-lymphodepletion chemotherapy (pre-LD). We hypothesized that changes in PET/CT between these time points predict outcomes after CAR-T.

Aug 6, 2023 | onlinelibrary.wiley.com | Matthew Ho |Saurabh Zanwar |Jonas Paludo

2.2.3 Tisagenlecleucel/Kymriah™ Tisa-cel, a second-generation anti-CD19 CAR-T-cell product with a 4-1BB co-stimulatory domain, is currently FDA approved for relapsed or refractory DLBCL, ALL (for patients up to 25 years), and follicular lymphoma (after ≥2 lines of therapy) (Figure 1).