Jonathan R. Thielman

Nov 21, 2023 | nature.com | Liam Hudson |Matthias V. Westphal |Jonathan R. Thielman |Bruce K. Hua |Christopher J. Gerry |Guoqin Xia | +10 more

Correction to: Nature Communications https://doi.org/10.1038/s41467-023-40575-5, published online 15 August 2023The original version of this Article contained an error in the email address provided in the Discussion section which was incorrectly given as [email protected]. The correct email address is [email protected]. This has now been corrected in both the PDF and HTML versions of the Article.

Aug 15, 2023 | nature.com | Liam Hudson |Matthias V. Westphal |Jonathan R. Thielman |Bruce K. Hua |Christopher J. Gerry |Guoqin Xia | +10 more

AbstractDiversity-oriented synthesis (DOS) is a powerful strategy to prepare molecules with underrepresented features in commercial screening collections, resulting in the elucidation of novel biological mechanisms. In parallel to the development of DOS, DNA-encoded libraries (DELs) have emerged as an effective, efficient screening strategy to identify protein binders. Despite recent advancements in this field, most DEL syntheses are limited by the presence of sensitive DNA-based constructs.