Jonel Trebicka

2 months ago | onlinelibrary.wiley.com | Jonel Trebicka |Qing Xie

Acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) represent critical junctures in the spectrum of liver diseases, characterized by rapid deterioration of liver function and often multi-organ dysfunction. Despite advances in medical care, they remain significant challenges in clinical practice, necessitating a deeper understanding of their pathophysiology and the development of effective therapeutic strategies.

Dec 13, 2024 | mdpi.com | Jonel Trebicka

2. Case ReportHere, we report a female patient who presented to our endocrinology outpatient clinic at the age of 30 in the eighth week of pregnancy for treatment of diabetes mellitus (Figure 1). She had hyperandrogenaemia and impaired glucose tolerance with insulin resistance since the age of 18.

May 10, 2024 | gut.bmj.com | Jonel Trebicka |Ruben Hernaez |Debbie Lindsay Shawcross |Alexander Gerbes

Challenges and opportunitiesPatient heterogeneity poses significant challenges for managing individuals and designing clinical trials, especially in complex diseases. Existing classifications rely on outcome-predicting scores, potentially missing crucial elements contributing to heterogeneity and impacting prognostic insights.

Mar 1, 2024 | onlinelibrary.wiley.com | Martin Schulz |Paolo Angeli |Jonel Trebicka

ACLF acute-on-chronic liver failure AD acute decompensation ALD alcoholic liver disease cACLD compensated advanced chronic liver disease CLIF-SOFA Chronic Liver Failure Sequential Organ Failure Assessment CSPH clinically-significant portal hypertension DAA direct-acting antiviral DAMP danger-associated molecular pattern EASL-CLIF European Foundation for the Study of Chronic Liver Failure ECLS extracorporeal liver support systems HBV hepatitis B virus HCC hepatocellular carcinoma HCV hepatitis...