Jorge A Cervilla

May 27, 2024 | nature.com | Ana M Pérez-Gutiérrez |Rosario Carmona |Carlos Loucera |Jorge A Cervilla |Blanca Gutierrez |Esther Molina | +3 more

AbstractMajor depression (MD) and obesity are complex genetic disorders that are frequently comorbid. However, the study of both diseases concurrently remains poorly addressed and therefore the underlying genetic mechanisms involved in this comorbidity remain largely unknown. Here we examine the contribution of common and rare variants to this comorbidity through a next-generation sequencing (NGS) approach.

Mar 13, 2023 | nature.com | Dongjing Liu |Brian K. Fennessy |Esther Cheng |Joseph D. Buxbaum |Enrico Domenici |Dheeraj Malhotra | +21 more

AbstractSchizophrenia (SCZ) is a chronic mental illness and among the most debilitating conditions encountered in medical practice. A recent landmark SCZ study of the protein-coding regions of the genome identified a causal role for ten genes and a concentration of rare variant signals in evolutionarily constrained genes1.