Joseph Gallagher

Apr 22, 2024 | biorxiv.org | Jeffrey A. Ruffolo |Stephen Nayfach |Joseph Gallagher |Aadyot Bhatnagar

AbstractGene editing has the potential to solve fundamental challenges in agriculture, biotechnology, and human health. CRISPR-based gene editors derived from microbes, while powerful, often show significant functional tradeoffs when ported into non-native environments, such as human cells. Artificial intelligence (AI) enabled design provides a powerful alternative with potential to bypass evolutionary constraints and generate editors with optimal properties.