Joseph L. Servadio

Oct 23, 2023 | biorxiv.org | Robert J. Zupko |Joseph L. Servadio |Tran Nguyen |Thu Tran

AbstractHistorically Plasmodium falciparum has followed a pattern of drug resistance first appearing in low transmission settings before spreading to high transmission settings. Several features of low-transmission regions are hypothesized as explanations: higher chance of symptoms and treatment seeking, better treatment access, less within-host competition among clones, and lower rates of recombination.