Joseph McKenna

Jan 17, 2025 | biorxiv.org | Rekha M Dhillon-Richardson |Alexandra K. Haugan |Luke Lyons |Joseph McKenna

AbstractDuring vertebrate development, the heart primarily arises from mesoderm, with crucial contributions from cardiac neural crest cells that migrate to the heart and form a variety of cardiovascular derivatives. Here, by integrating bulk and single cell RNA-seq with ATAC-seq, we identify a gene regulatory subcircuit specific to migratory cardiac crest cells composed of key transcription factors egr1, sox9a, tfap2a and ets1.