Josephine Mun-Yee Ko

Jan 2, 2025 | jci.org | Yanni Zeng |Chun-Ling Luo |Guo-Wang Lin |Fugui Li |Xiaomeng Bai |Josephine Mun-Yee Ko | +12 more

AbstractNasopharyngeal carcinoma (NPC) presents a substantial clinical challenge due to the limited understanding of its genetic underpinnings. Here we conduct the largest scale whole-exome sequencing association study of NPC to date, encompassing 6,969 NPC cases and 7,100 controls. We unveil 3 germline genetic variants linked to NPC susceptibility: a common rs2276868 in RPL14, a rare rs5361 in SELE, and a common rs1050462 in HLA-B.