Joshua Atkins

Apr 28, 2024 | nature.com | Karl Smith-Byrne |Marios Dimitriou |Mine Koprulu |Maik Pietzner |Claudia Langenberg |Joshua Atkins | +10 more

AbstractCirculating proteins can reveal key pathways to cancer and identify therapeutic targets for cancer prevention. We investigate 2,074 circulating proteins and risk of nine common cancers (bladder, breast, endometrium, head and neck, lung, ovary, pancreas, kidney, and malignant non-melanoma) using cis protein Mendelian randomisation and colocalization. We conduct additional analyses to identify adverse side-effects of altering risk proteins and map cancer risk proteins to drug targets.