Joshua D. Schiffman

Nov 27, 2024 | onlinelibrary.wiley.com | Mia Hashibe |Kimberly Herget |Joshua D. Schiffman |Vivian Chang

1 INTRODUCTION Incidence rates of acute myeloid leukemia (AML) in the Asian, Native Hawaiian, and Pacific Islander (ANHPI) population may be increasing statistically significantly in contrast to acute lymphoid leukemia (ALL) rates, which did not show changes over the 2000–2019 period.1 Upon disaggregation of the ANHPI population, incidence rate ratios showed no differences for East Asian, Filipino, and Asian Indian and Pakistani populations for childhood leukemia when compared to the...

Aug 24, 2023 | nature.com | Rachael Natrajan |Lisa M. Abegglen |Joshua D. Schiffman |Marcela Braga Mansur

AbstractThe emergence of drug-resistant cells, most of which have a mutated TP53 gene, prevents curative treatment in most advanced and common metastatic cancers of adults. Yet, a few, rarer malignancies, all of which are TP53 wild type, have high cure rates. In this Perspective, we discuss how common features of curable cancers offer insights into the evolutionary and developmental determinants of drug resistance. Acquired loss of TP53 protein function is the most common genetic change in cancer.

Jan 5, 2023 | nature.com | Joshua D. Schiffman

Apr 5, 2020 | daily.jstor.org | Joshua D. Schiffman

Apr 8, 2019 | healio.com | Joshua D. Schiffman