Joshua W. Morse

Aug 12, 2024 | digitalcommons.library.tmc.edu | Joshua W. Morse |Xun Gui |Mi Deng |Ryan Huang

AbstractThe immune checkpoint leukocyte immunoglobulin-like receptor B4 (LILRB4) is found specifically on the cell surface of acute monocytic leukemia (monocytic AML), an aggressive and common subtype of AML. We have developed a humanized monoclonal IgG1 LILRB4-blocking antibody (h128-3), which improved immune regulation but reduced cell surface expression of LILRB4 in monocytic AML models by 40–60%.