Joshua W. Shaevitz

Nov 20, 2024 | biorxiv.org | Handuo Shi |Jeffrey P. Nguyen |Zemer Gitai |Joshua W. Shaevitz

AbstractUnderstanding the mechanisms that dictate the localization of cytoskeletal filaments is crucial for elucidating cell shape regulation in prokaryotes. The actin homolog MreB plays a pivotal role in maintaining the shape of many rod-shaped bacteria such as Escherichia coli by directing cell-wall synthesis according to local curvature cues. However, the basis of MreB's curvature-dependent localization has remained elusive.