Joshua Wong

May 28, 2024 | thelancet.com | Joshua Wong |Timothy McCulloch |Louisa Alim |Natacha Omer

SummaryNatural killer (NK) cells are important innate immunity players and have unique abilities to recognize and eliminate cancer cells, particularly in settings of antibody-opsonization and antibody-dependant cellular cytotoxicity (ADCC). However, NK cell-based responses in bladder cancers to therapeutic antibodies are typically immunosuppressed, and these immunosuppressive mechanisms are largely unknown.